Why Oral Vaccines May Be Less Effective Person

Why Oral Vaccines May Be Less Effective

According to TASS, scientists from the University of Pittsburgh have found that disturbances in the intestinal microflora cause frequent inflammation, which, in turn, leads to the appearance of a large number of regulatory T cells that suppress these processes. A side effect of their work is that they prevent the accumulation of cells in the digestive organs associated with the development of a reaction to vaccines.

There are about ten times more bacteria, fungi and other microflora in the human body than there are cells. For a long time it was believed that the composition of the microflora affects only the metabolism, but studies show that this extends to the likelihood of getting cancer and other diseases, as well as the behavior of humans and animals. Transplantation of healthy microflora helps obese rodents lose weight, and fatty foods promote the reproduction of microbes in the intestine that accelerate obesity and rectal cancer.

Finding out how the species composition and behavior of microflora changes in chronic malnutrition or infections of the gastrointestinal tract, researchers noticed an unusual role of microflora in the reaction of humans and mammals to oral vaccines. In developing countries, doctors have long noticed that vaccines have a worse effect on those people who suffer from chronic diseases or a prolonged lack of calories, but doctors did not know the reasons for this.

To understand, biologists developed a diet with a small amount of proteins and fats, and also periodically introduced cultures of dangerous microbes into the digestive system of rodents, causing inflammation and digestive failures and this led to serious disturbances in the intestinal microflora. After some time, scientists introduced an oral vaccine into the body of mice, which is designed to protect against infection with those strains of E. coli, which causes serious problems with digestion of food.

Observations have shown that disturbances in the microflora were associated with a decrease in the effectiveness of oral vaccines. The reason was the fact that malfunctions in the vital activity of the microflora had a special effect on the behavior of two types of T cells, one of which suppresses inflammation, and the other is involved in the development of a reaction to vaccines entering the digestive system.

The activity of cells of the first type increased, and of the second type decreased. Having found out the important role of inflammation and associated cells in reducing the effectiveness of vaccines, experts attempted to suppress this effect with the help of antibiotics — it turned out that this procedure helped to strengthen the effect of vaccines on the body of rodents. Thus, scientists believe, this procedure can improve the quality of vaccinations.