Scientists have described how psilocybin dissolves a person's ego: brain chemistry Person

Scientists have described how psilocybin dissolves a person's ego: brain chemistry

The experience of taking psychedelics can be completely different, and sometimes very frightening. People experimenting with magic mushrooms often describe their condition as a kind of loss, the disintegration of their own personal qualities. Some then radically change their lives, others never touch mushrooms and stamps again.

Until now, scientists could only observe the effects of psychoactive substances and record the testimony of the subjects. But recently, they have studied for the first time how taking psilocybin affects the activity of glutamate, a special substance that is produced in the brain during the impact on the psyche.

In 2020, using MRI, a team of scientists examined the brain activity of 60 healthy volunteers and found that bad and good trip is directly related to the concentration of this substance in the brain. Glutamate is the most common neurotransmitter in the brain and plays a crucial role during the rapid transmission of signals and information, especially in the cortex and hippocampus. It is noteworthy that modern medicine believes that it is the hippocampus that plays a decisive role in a person's self-esteem.

It seems that psychedelics have a way to connect to this system.

Interestingly, in a new clinical study, both brain regions had completely different glutamate responses to psilocybin. Although the authors found higher levels of glutamate in the prefrontal cortex during the trip, they also detected a decrease in glutamate levels in the hippocampus.

In fact, science has not yet deduced a clear connection between the brain activity described above and our ego. However, it has been suggested that psychedelics to some extent separate brain regions from each other, so factual or autobiographical information becomes momentarily separated from a sense of personal identity.

Our data complement this hypothesis, suggesting that hippocampal glutamate modulations may be a key mediator provoking ego "dissolution", the authors suggest.